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Olanzapine 15 mg cost -effectively in patients with bipolar I disorder: results from a randomized, double-blind, placebo-controlled, multicenter trial. JAMA Psychiatry 59, 955–961 (2006). 58. Tackett, A. J. et al. Efficacy and tolerability of escitalopram 20 mg as initial first-line maintenance therapy in the first episode of schizophrenia: results the PACE trial. Lancet 359, 1349–1354 (2002). 59. van der Kolk, A. J., Faraone, S. V., Fava, A. M. & Vollenweider, F. X. Antidepressant effects of ketamine versus fluoxetine in patients with major depressive disorder. Neuropsychopharmacology 35, 735–746 (2005). This was at the forefront of a re-evaluation ketamine's antidepressant actions, and there is now more evidence that it is likely to be a safe and effective treatment, although it is not without side effects. 60. De Petrocellis, E. T. et al. Ketamine treatment for depression in adult outpatients presenting with a depressive disorder: randomized, controlled pilot study. J. Am. Acad. Child Adolesc. Psychiatry 51, 1735–1742 (2006). This was the first small-scale, placebo-controlled study, to our knowledge, specifically test the antidepressant effect of ketamine. As is common with research involving young children, the control group received usual care. 61. Tackett, A. J. et al. A double-blind study of the efficacy and tolerability escitalopram 20 mg as initial first-line maintenance treatment for bipolar I disorder: results from a randomized, double-blind, placebo-controlled clinical trial. Am. J. Psychiatry 163, 1731 (2007). 62. de Wit, J. L. et al. Effects of ketamine on human emotional responses. Arch. Gen. Psychiatry 59, 478–484 (2005). 63. Agerbo, H., Jonsson, J., Tackett, A. J. & Gage, T. R. Long-term use of intravenous vs. subcutaneous ketamine versus prazosin for treatment-resistant depression in the ACT:A study. J. Clin. Psychiatry 68, 853–860 (2009). 64. Bouso, V. R. et al. Efficacy and tolerability of extended-release buprenorphine versus naltrexone for major depressive disorder: results of a randomized controlled clinical trial. J. Clin. Psychiatry 71, 29–38 (2013). 65. Bouso, V. R., Tannock, A., De Wit, J. L., Petrocellis, E. T. & van der Kolk, A. J. Long-term maintenance of buprenorphine treatment as compared to naltrexone maintenance for treatment-resistant depression: results of a multicenter randomized controlled trial. JAMA Psychiatry 69, 1163–1170 66. Bouso, V. R. et al. Efficacy and risk-benefit of buprenorphine versus naltrexone maintenance treatment for treatment-resistant depression: results of a randomized, double-blind, placebo-controlled pilot study. J. Clin.

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